Meaney was found at his home in Forestburgh, New York, agent Tom Ingegno said. His age and the cause of death weren't immediately known.
Meaney was scheduled to perform Saturday night in Rhode Island, according to his website
After his first HBO special in 1986, Meaney was catapulted to the spotlight and debuted on "The Tonight Show" with Johnny Carson the following year, according to Meaney's website. He returned to the show a dozen times.
Meaney starred in the CBS sitcom "Uncle Buck," which ran for one season in 1990, and appeared on "Saturday Night Live."
Fellow comedians were quick to offer condolences on Twitter.